In order to understand the mechanism of anticoagulation
by coumarins, the system described above has been extensively
studied in various in vitro systems from rat liver (1, 2). Since
these drugs are used so frequently in patients, we decided to
study the system in human liver. Our goal was to determine
how closely the enzyme system in human liver corresponded to
the model established for the action of vitamin K and coumarins
in rat liver.