Towards the north of the constellation are globular clusters NGC 5824 and NGC 5986, and close by the dark nebula B 228. To the south are two open clusters, NGC 5822 and NGC 5749, as well as globular cluster NGC 5927 on the eastern border with Norma. On the western border are two spiral galaxies and the Wolf-Rayet planetary nebula IC 4406, containing some of the hottest stars in existence. IC 4406, also called the Retina Nebula, is a cylindrical nebula at a distance of 5,000 light-years. It has dust lanes throughout its center.[3] Another planetary nebula, NGC 5882, is towards the centre of the constellation. The transiting exoplanet Lupus-TR-3b lies in this constellation. The historic supernova SN 1006 is described by various sources as appearing on April 30 to May 1, 1006, in the constellation of Lupus.
ESO 274-1 is a spiral galaxy seen from edge-on that requires an amateur telescope with at least 12 inches of aperture to view. It can be found by using Lambda Lupi and Mu Lupi as markers, and can only be seen under very dark skies. It is 9 arcminutes by 0.7 arcminutes with a small, elliptical nucleus.[4]