In this study, we investigated the bioconversion of the wild inedible cassava to bioethanol by S. cerevisiaein (i) a co-culture mode with an amylolytic strain ofAspergillussp., and compare it with (ii) a monoculture mode employing an enzyme preparation from the Aspergillussp. The study tests the potency of the amylolytic enzyme when secreted in situ during the co-culture fermentation and when prepared and used together with the fermenting microorganism