1.3 Previous Work Classification
1.3.1 M0 Acute myeloblastic leukemia with minimally differentiated
This subtopic presents AML-M0 is most common in adult patients. Accounts for approximately 5-10% of all AML patients. WBCs show Leukocytosis in 40% and > 50% with leukocytopenia. The diagnosis is made if less than 3% of the blasts are positive for peroxidase or the Sudan black B reaction and if the Blasts are positive for the myeloid-associated markers CD13, 14, CD15 or CD33, CD34 and negative for B or T lineage marker (CD3, CD10, CD19 and CD5). Bone marrow aspirated was hypercellular in all patients and contained a large number of leukemic blasts (Bennette JM 1991). Almost no mature myeloid cells were seen. The blasts were small to medium-sized round cells with an eccentric nucleus. The nucleus often had a flattened shape and was sometimes lobulated or cleaved and contained fine chromatin with several distinct nucleoli. The cytoplasm was lightly basophilic without granules. Auer rods are not found.