ABSTRACT
The aim of the present investigation was to evaluate the therapeutic efficacy of Eugenia Jambolana in an animal
model of diabetes. Diabetes was induced in albino rats by administrating Streptozotocin 50mg/kg intraperitonial .
Normal as well as diabetes albino rats were divided into groups (n=5) receiving different treatment: Control
(vehicle) , diabetic (vehicle) ethanolic pulp extract (200mg/kg) ethanolic seed extract (200mg/kg) and standard
antidiabetic drug glibenclamide (.6mg/kg b.w.) Blood samples collected from retro orbital sinus and estimated for
blood sugar lipid profile, glycosylated haemoglobin blood urea on day 0, 7, 14 and 21. The effect on body weight
was also observed. Blood glucose level, lipids and blood urea were elevated in diabetic group but were significantly
brought down with treatment with seed and pulp extract. There was improvement in body weight with treatment.
Eugenia Jambolana pulp and seed extract at a done of 200mg/kg body weight has therapeutic effect in diabetes
induced albino rats. Therefore this investigation reaffirms the potential of EJ as natural oral agent as add on therapy
to established oral hypoglycaemic agents and/or insulin. Further studies to isolate and characterize the active
compound and to further elucidate the mechanism involved in the hypoglycaemic needs to be done.
Key word: Eugnia Jambolana , Diabetes Mellitus, Streptozotocin, Hypolipidemia and Hypoglycaemia