women, we noted that 28% of high-risk patients did not receive adjuvant
chemotherapy.
Although there is consensus about the benefit of adjuvant chemotherapy
for high-risk patients, the optimal duration of chemotherapy
remains controversial. While a clinical trial comparing three versus six
cycles of chemotherapy demonstrated no survival benefit with six cycles
of therapy, these datawere only powered to detect N30% difference
in survival . Post-hoc analysis of the GOG data suggested that some
groups of women, particularly those with serous histology, derive benefit
from longer duration chemotherapy . Our findings are in line
with the GOG's data in that there was no improvement in survival for
high-risk, early-stage patients treated with longer duration
chemotherapy.