Generally crops with resistance to viral disease may be developed through genes derived from viral sequences providing pathogen derived resistance (PDR), genes from various other sources that can interfere with target virus, and natural resistance genes. The concept of pathogen derived resistance (PDR) is a new approach for PRSV management. Pathogen derived genes interfere with the replication process of viruses in their host plants in different ways. So far, PRSV-resistant transgenic papaya has been developed through coat protein (CP), RNA silencing, and replicase gene technology.