gave a multinutrient supplement containing
150 mg iodine/day or control to pregnant
Danish women positive for anti-thyroid peroxidase
antibodies (TPO-Ab) (n = 66) from 11 weeks to term.26
Median UIC was significantly higher in the treated
women at term, but there were no differences in
maternal TSH, FT4 or Tg between groups. Finally, in a
prospective, randomised, open-label trial, Antonangeli
et al. supplemented pregnant Italian women
(n = 67; median UIC 74 mg/g creatinine) with 50 mg or
200 mg iodine/day from 18–26 weeks to 29–33 weeks
of gestation.27 Median UIC was significantly higher in
the 200 mg group than in the 50 mg group (230 vs.
128 mg/g creatinine). However, there were no differences
in maternal FT4, FT3, TSH, Tg or thyroid volume
between groups.