Women who are taking up to
1.1mg folic acid are eligible for the trial, and since we will not
ask the women to change their practice; the total dose of folic
acid maybe up to 5.1mg in the trial arm (4.0mg from trial
medication and 1.1mg fromroutine supplementation) and up
to1.1mg in the placebo arm (from routine supplementation),
which is consistent with SOGC’s recommendation for high
risk pregnancy