The figure above shows the necessary “Health Benefit Cascade” of steps that have been evaluated on POMELLA® Extract and pomegranate polyphenols, notably the punicalagins within the natural spectrum of pomegranate. The POMELLA® Extract research program addresses a number of issues that have historically plagued substantiation and proof of efficacy for dietary supplements. These issues include a lack of knowledge of specific antioxidant pharmacokinetics, metabolism, and pharmacodynamics; a lack of achieving efficacious blood and organ concentrations; and inadequate study design.
In summary, POMELLA® Extract and the natural spectrum of pomegranate polyphenols have been shown highly potent on the molecular and cellular scales, and these activities, along with antioxidant synergy and bioavailability, have translated into efficacy on the systemic scale, including those involved in cardiovascular, oral, skin and other health benefits.