Recently, a stability indicating HPLC–UV method was
reported by Gugulothu and Patravale (2012) for determination
of curcumin and celecoxib in nanoparticle formulation. The result
showed that curcumin in solution was not stable and degraded
after 1 h of stress studies. Curcumionoids are polyphenols and
decomposed when exposed to high temperature (Schieffer, 2002).