MAP and HR in mice increased sharply after handling, despite 3 weeks of habituation to the procedure. Under
stressful conditions of open field test cardiovascular parameters in mice were elevated and did not depend on
movement speed. HR values did not differ in I and SAL groups and were reduced with A or A + I. HR was
lower at rest in D pretreated mice. In the treadmill test HR increase over speeds of 6, 12 and 18 m/min was roughly
1/7–1/10 of HR increase observed after placing the mice on the treadmill. HR could not be increased with
cholinolytic (I), but was reduced after sympatholytic (A) or A + I treatment. Anxiolytic (D) reduced heart rate
at lower speeds of movement and its overall effect was to unmask the dependency of HR on running speed. During
voluntary running in non-stressful conditions of the home cage HR in mice linearly increased with increasing
running speeds