Despite these optimistic findings in vitro, the use of honey in clinical practice today as an antimicrobial agent does not appear to have yet reached its full potential. Innovative research that can maximally exploit the antimicrobial properties of this natural substance and overcome obstacles associated with in vivo use may, in the future, lead to the production of an antimicrobial agent that is highly valued in clinical practice. Interestingly, no honey-resistant microbial strains have emerged to date, and this may be unlikely because of the multifactorial nature of the antimicrobial properties of honey. As honeys from diverse floral origins have been shown to have antimicrobial activity against a range of skin relevant microbes, research should continue to investigate the efficacy of honey in the treatment of other types of skin disorders where microbes have been implicated in the pathophysiology of the disease. There are countless varieties of honeys being produced worldwide, and some may have superior antimicrobial activities that are yet to be discovered.