Severely or morbidly obese persons are, on the
average, about 10 to 12 BMI units heavier than
their parents and siblings. Several studies have
reported that a single major gene for high body
mass was transmitted from the parents to their
children. The trend implies that a major recessive
gene, accounting for about 20 to 25 percent
of the variance, is influenced by age and has a
frequency of about 0.2 to 0.3. 343 However, no
gene(s) has (have) yet been identified. Evidence
from several studies has shown that some persons
are more susceptible to either weight gain
or weight loss than others. 344,345 It is important
for the practitioner to recognize that the phenomenon
of weight gain cannot always be
attributed to lack of adherence to prescribed
treatment regimens.
Severely or morbidly obese persons are, on the
average, about 10 to 12 BMI units heavier than
their parents and siblings. Several studies have
reported that a single major gene for high body
mass was transmitted from the parents to their
children. The trend implies that a major recessive
gene, accounting for about 20 to 25 percent
of the variance, is influenced by age and has a
frequency of about 0.2 to 0.3. 343 However, no
gene(s) has (have) yet been identified. Evidence
from several studies has shown that some persons
are more susceptible to either weight gain
or weight loss than others. 344,345 It is important
for the practitioner to recognize that the phenomenon
of weight gain cannot always be
attributed to lack of adherence to prescribed
treatment regimens.
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