As mentioned above, components of adhesives for use in food packaging that are not the subject of a food additive regulation, GRAS or prior sanctioned may still be used if they are not reasonably expected to become a component of the food. This can be determined through migration studies. In designing migration studies, an understanding of the intended use of the adhesive is necessary. For example, will it be used in a multilayer laminated package or a paper box or some other structure? Samples for testing must be prepared under the same manufacturing conditions as the end use. These include film types and thickness, amount of adhesive used, adhesive composition and cure times.