Since acupuncture at GV20 and ginger extract individually have many health benefits, we hypothesized that the combination of these treatments might further ameliorate brain damage and memory impairment in stroke condition. Since oxidative stress has been reported to play a crucial role in the pathophysiology of ischemic stroke, this study aimed to determine the effect of ginger pharmacopuncture on brain damage in the cerebral cortex and hippocampus and on oxidative stress markers in this area.