4.1 Target-site Resistance
It occurs when the site of action of an insecticide (typically within the nervous system) is modified in resistant strains, such
that the insecticide no longer binds effectively and the insect is therefore unaffected, or less affected by the insecticide.
Resistance mutations known as knock-down resistance mutations, can affect acetylcholinesterase, which is the molecular target of organophosphates and carbamates, or may be voltage-gated sodium channels