High hydrostatic pressure has a marked effect on non-covalent interactions, which play an important role in the stabilization of biological systems, such as membrane and proteins. As a matter of fact, lipid oxidation in food must be contextualized within a broader phenomenon of destabilization of cellular components. It seems plausible that the accumulation of pro-oxidants molecules and lipolytic enzymes in the tissue fluids of foods treated with high pressure can be a major contributor to the observed increase in lipid oxidation.