The potential accumulation of these metals in the organisms inhabiting the Butuanon River [10] has never been assessed. People fish along the Butuanon River for household consumption [9] and for commercial purposes. Using the catfish (Clarias macrocephalus) as a bioindicator [4], it is the aim of this study to determine if this fish has accumulated Cu, Pb and Zn from its ambient environment and if it is safe for human consumption.