Multiple geophysical parameters including groundwater level, water temperature, water radon, crustal deformation, electromagnetic waves and total electron contents (TEC) in the ionosphere, are examined together to investigate pre-earthquake anomalous phenomena associated with the Mw6.1 Ludian earthquake on August 3, 2014. Cross-parameter comparison eliminates anomalies that are detected in one parameter only and examine earthquake-related phenomena in various fields, simultaneously.