Several epidemiological studies have shown that regular consumption of soy-based products, or other vegetables high in phytoestrogens, as part of a normal balanced diet can exert a protective influence against later development of breast cancer. This effect has been studied extensively in China, where soy intake is a regular part of the cultural diet. There, substantial evidence indicates that higher soy intake in adulthood or in adolescence is associated with a decreased risk of pre-menopausal breast cancer (Lee, 2009). Other studies have found protective effects of soy intake for both pre- and post-menopausal cancer, independent of the tumors’ receptor profile (estrogen-receptor and progesterone-receptor positive or negative) (Zhang, 2009). On the other hand, in a prospective study of women aged 43 to 55 years who had never been diagnosed with breast cancer but were considered to be at high risk, six months of dietary isoflavone (PTIG-2535, containing 150 mg genistein, 74 mg daidzein, and 11 mg glycitein) intake was associated with increased proliferation of breast cells. The effect was most pronounced in pre-menopausal women (Khan, 2012a).
For Chinese women w
Several epidemiological studies have shown that regular consumption of soy-based products, or other vegetables high in phytoestrogens, as part of a normal balanced diet can exert a protective influence against later development of breast cancer. This effect has been studied extensively in China, where soy intake is a regular part of the cultural diet. There, substantial evidence indicates that higher soy intake in adulthood or in adolescence is associated with a decreased risk of pre-menopausal breast cancer (Lee, 2009). Other studies have found protective effects of soy intake for both pre- and post-menopausal cancer, independent of the tumors’ receptor profile (estrogen-receptor and progesterone-receptor positive or negative) (Zhang, 2009). On the other hand, in a prospective study of women aged 43 to 55 years who had never been diagnosed with breast cancer but were considered to be at high risk, six months of dietary isoflavone (PTIG-2535, containing 150 mg genistein, 74 mg daidzein, and 11 mg glycitein) intake was associated with increased proliferation of breast cells. The effect was most pronounced in pre-menopausal women (Khan, 2012a).For Chinese women w
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