A non-compartmental approach applying thle
concept of statistical moments to pharmacokinetic
data analysis has been widely accepted and used
since its introduction by Yamaoka et al. [ 11, Cutler
[2], and Benet and Galeazzi [3]. A number of com-
puter programs have been developed for such cal-
culations including area-under the curve (AUC),
area-under the moment curve (AUMC), mean resi-
dence ?ime (MRT), and mean transit time (MTT)