In women age between 40–44 years-old, the prevalence of osteoporosis is only 0.9% and increase to over 30% at age of 70 years-old [20]. Estrogen deficiency has been recognized as a key factor of osteoporosis development [9]. Besides estrogen deficiency, alteration of cytokine production plays a role in the pathogenesis of osteoporosis, namely increasing of cytokine might increase osteoporosis prevalence in postmenopausal women [21].