V
olume overload, a common
complication of fuid resuscita-
tion, is frequently encountered
in the intensive care unit (ICU) and
is associated with numerous adverse
effects, including pulmonary and
peripheral edema, acute lung injury,
and pleural effusions. Loop diuret-
ics are potent drugs used to treat
volume overload and acute renal
failure and to ameliorate their as-
sociated complications.