This analysis confirms that ACEI/ARB therapy is superior to CCB therapy for the management of albuminuria in patients with hypertension and diabetes. However, it also suggests that the net difference in albuminuria reduction between both drug classes is small in the overall population and absent in patients with severe albuminuria. As a result, CCB may be a reasonable choice for blood pressure control and albuminuria reduction in cases of intolerance or lack of blood pressure response to ACEI/ARB.