treatment, means of MDA level decreased in both groups, however, the difference were not statistically significant. DISCUSSION The results of this study showed that the extract of mangosteen rind was effective in reducing number of acne lesions. These results are consistent with in vitro study by Chomnawang, et al11,12 demonstrating that EMR has anti-bacterial properties against Propionibacterium acnes and anti-inflammatory activity.11,12 Based on the success rate criteria (reduction of number of acne lesion ≥ 20%), the benefit of EMR on non-inflamed lesions (comedos) was higher (63%) than inflamed lesions (papules &pustules) (35%), although statistically the difference was not significant