4. Conclusion
The lack of knowledge on the dominant pharmaceutical TPsformed in environmental systems limits the development of conventional target analytical approaches for these potential environmental contaminants and thus hampers comprehensive research on environmental distribution, persistence, and ecotoxicological effects of TPs. Given the large number of organic pollutantsin the environment, an efficient method to identify key TPs thatare of environmental relevance from a persistence point of view is indispensable. This can be accomplished at satisfactory efficiency,data processing cost, and reliability, by the approach presentedin this study, which is based on state-of-the-art LC/HRMS and athree-step in silico data treatment