Apoptosis is throuqh the mitochondrial or intrinsic pathway this is set motion by dna damage bothways ultimatary stimulate a set of enzyme called capases intract with inhibitors of apoptosis protein on I ap and the bcl family of proteins which individually have either pro and anti a pop topic proprerties in some malignant cell there is resistance to apoptosis due to overexpression of anti ap pop tonic protein for example survivin is an iap that is foud in many cancer and predicts for por outcomes and bcl-2 overexpressed in b-cell lymphomas us a result of the translocation of its gene conversely activating mutations of pro-apoptotic molecule like backs is seen in some dastrointestinal tumors and leukemias anti cancer agents have been developed tardeting antipop tonic molecules for instance short segaments of dna