In this study, DHSA was produced in a 500-kg-per-batch operation
pilot plant, according to the patented procedure (Ahmad et al.,
2009). The waxy crude DHSA was then purified to remove dermal
irritants, such as octanoic and decanoic acids. This study aims to
investigate the effects of temperature and solvent concentration
on weight-based crystal yield, particle size distribution, and purity
and process efficiency in the crystallization of DHSA with isopropyl
alcohol (IPA) as the solvent.
In this study, DHSA was produced in a 500-kg-per-batch operationpilot plant, according to the patented procedure (Ahmad et al.,2009). The waxy crude DHSA was then purified to remove dermalirritants, such as octanoic and decanoic acids. This study aims toinvestigate the effects of temperature and solvent concentrationon weight-based crystal yield, particle size distribution, and purityand process efficiency in the crystallization of DHSA with isopropylalcohol (IPA) as the solvent.
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