long with aging and acne concerns, uneven pigmentation is one of the most common complaints skin care professionals hear in the treatment room. Changes in skin pigmentation can occur due to many different factors and can be the most difficult issue to tackle in the treatment room. Perhaps one of the most challenging pigmentary conditions to treat is melasma, a common disorder of hyperpigmentation that affects more than five million Americans.1 Melasma predominantly affects women with Fitzpatrick phototypes III through VI, or those with ancestry stemming from equatorial regions where ultraviolet radiation (UVR) is highest. Although sun exposure and hormones are closely associated with triggering, much remains to be understood about the origin and development of the disorder.