VIP exerts a strong vasodilatatory effect on the craniocervical vasculature
(Edvinsson and Uddman, 2005). One clinical study revealed that
a VIP infusion causes strong dilatation of the superficial temporal artery,
but none of the patients reported migraine attacks (Rahmann et al.,
2008). Itwas recently reported that a VIP infusion induced marked dilatation
of the extracranial, but not the intracranial arteries in female
migraineurs without aura, and only 18% of the migraine patients experienced
migraine-like attacks (Amin et al., 2014).
Overall, therefore, VIP is a strong vasodilatorwith a lowcapability to
induce a migraine attack.
VIP exerts a strong vasodilatatory effect on the craniocervical vasculature(Edvinsson and Uddman, 2005). One clinical study revealed thata VIP infusion causes strong dilatation of the superficial temporal artery,but none of the patients reported migraine attacks (Rahmann et al.,2008). Itwas recently reported that a VIP infusion induced marked dilatationof the extracranial, but not the intracranial arteries in femalemigraineurs without aura, and only 18% of the migraine patients experiencedmigraine-like attacks (Amin et al., 2014).Overall, therefore, VIP is a strong vasodilatorwith a lowcapability toinduce a migraine attack.
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