Our study found that higher neighbourhood deprivation was associated with lower smoking intensity among a cohort of smokers in Mexico between 2010 and 2012. These findings are in contrast to results from HICs. The next step in this research will be to understand which specific characteristics of more deprived neighbourhoods are acting as buffers against worse smoking outcomes. In addition, it is unclear if these patterns will hold in other LMICs. If so, understanding these environments may help reduce and prevent smoking-related health disparities around the world.