1. Introduction
Malaria is a major health problem in many developing countries,
mostly in Africa and Southeast Asia (Snow et al., 2005).
According to WHO report on malaria (2007), 40% world’s population
is living with risk of malaria, over 1.5 million death occur
per year and the cost of malaria treatment is $1800 million US
dollar. The first effective antimalarial drug was quinine, which
was isolated from the bark of cinchona. Since then malaria has
been treated with quinoline based drugs. However, Plasmodium
falciparum developed resistant globally against two of the most
common antimalarial drugs: chloroquine and the combination sulphadoxine/
pyrimethamine (Ridely, 2002).