Local anatomy
1. Mandible
a. Lingual tori
b. Mylohyoid ridge
2. Maxilla
a. Palatal tori
It has been observed that lesions are found more commonly in the mandible than the
maxilla (2:1 ratio) and more commonly in areas with thin mucosa overlying bony
prominences such as tori, bony exostoses and the mylohyoid ridge.No data are
available to provide risk estimates for anatomic structures and BRONJ.
C. Concomitant oral disease
Cancer patients exposed to IV bisphosphonates with a history of inflammatory dental
disease, e.g., periodontal and dental abscesses, are at a seven-fold increased risk for
developing BRONJ.