In view of the relatively high titers, the itaconate biosynthesis is
expected to be a dominant biological pathway in A. terreus. Most
likely, the itaconic acid specific genes are expressed in elevated
levels under itaconate-producing conditions, making a transcriptomics
approach a good option to identify these genes. In line with
this, recently it has been demonstrated that transcriptomics is a
valuable tool in identifying the relevant genes involved in primary
metabolism (van der Werf et al., 2006). Therefore, in our study, we
have used a transcriptomics based approach for identifying itaconic
acid production related genes from A. terreus.
In view of the relatively high titers, the itaconate biosynthesis isexpected to be a dominant biological pathway in A. terreus. Mostlikely, the itaconic acid specific genes are expressed in elevatedlevels under itaconate-producing conditions, making a transcriptomicsapproach a good option to identify these genes. In line withthis, recently it has been demonstrated that transcriptomics is avaluable tool in identifying the relevant genes involved in primarymetabolism (van der Werf et al., 2006). Therefore, in our study, wehave used a transcriptomics based approach for identifying itaconicacid production related genes from A. terreus.
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