Recent studies indicate that another hypothesis,called metal hypothesis,may contribute to AD pathology.
It is observed that the level of metal ions (Fe,Cu,Zn) in AD patients is 3-7 folds higher than that of healthy individuals.
the abnormal accumulation of metals is able to accelerate the formation of aggregates and neurofibrillary tengles, which promote inflammation and activate neurotoxic pathways, leading to dysfunction and death of brain cells.