Recent papers observed an amputation
rate of 22% to 44% in ESRD patients affected
by ischaemic foot lesions. In this context the
negative impact of uraemia in the wound healing
process is well defined. Even if all mechanisms
are not clear, this condition seems to
depress cellular proliferation at wound edges and
reduce fibroblast growth.46 Further it has been
documented that wound strength and granulation
tissue mass are impaired in diabetic uremic
wounds.