Results
Table 1 presents theHLA class I allele profiles for the patients
with delusional disorder, for those with paranoid schizophrenia,
and for the healthy control subjects. The results demonstrate
a marked elevation (60%) of the frequency of
HLA-A*03 (÷2 = 43.20, P < 0.01) in patients with delusional
disorder, compared with control subjects (15%). Statistically,
this was highly significant. In addition, we observed a less significant
increase in the frequency of HLA-A*11 (24% in the
patients with delusional disorder, compared with 12% in control
subjects). When we compared the frequency of B-locus
alleles, we also noticed increased frequency of B*5001 in this
patient group (25%, compared with 15% for the control subjects),
but it did not reach statistical significance. Apart from
this, several alleles, such as A*01 (3% for patients, compared
with 12% for control subjects) and B*1501 (5% for patients,
compared with 13% for control subjects), showed decreased
frequency, although it was not statistically significant.