a b s t r a c t
Amidst growing environmental awareness and stringent discharge regulations, chemical and allied pro-
cess industries are now desperately seeking replacement of the conventional, polluting processes by
clean and green processes. In this context, production and purification of amino acids like l-glutamic
acid assumes significance. Concerned conventional process involves several steps like fermentation, cen-
trifugation, carbon adsorption, evaporation, crystallization, ion-exchange and so on to get glutamic acid
in desired concentration and purification. Despite its tremendous potential for large scale use in a wide
variety of applications, cost-effective production of high purity glutamic acid has remained a challenge
for decades, mainly due to several downstream processing steps and the associated cost factors. With
emergence of tailor-made membranes and modules, possibility of using membranes in downstream
purification of glutamic acid appears imminent with expectation of a turnaround in amino acid manu-
facturing industry. The present study through a brief yet comprehensive review ofthe very critical aspects
of glutamic acid production and purification, attempts to direct research efforts towards process inten-
sification encompassing the concepts of green processing, compact and flexible design with promise of
more economically attractive production with better quality.
a b s t r a c tAmidst growing environmental awareness and stringent discharge regulations, chemical and allied pro-cess industries are now desperately seeking replacement of the conventional, polluting processes byclean and green processes. In this context, production and purification of amino acids like l-glutamicacid assumes significance. Concerned conventional process involves several steps like fermentation, cen-trifugation, carbon adsorption, evaporation, crystallization, ion-exchange and so on to get glutamic acidin desired concentration and purification. Despite its tremendous potential for large scale use in a widevariety of applications, cost-effective production of high purity glutamic acid has remained a challengefor decades, mainly due to several downstream processing steps and the associated cost factors. Withemergence of tailor-made membranes and modules, possibility of using membranes in downstreampurification of glutamic acid appears imminent with expectation of a turnaround in amino acid manu-facturing industry. The present study through a brief yet comprehensive review ofthe very critical aspectsof glutamic acid production and purification, attempts to direct research efforts towards process inten-sification encompassing the concepts of green processing, compact and flexible design with promise ofmore economically attractive production with better quality.
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