In conclusion, our findings support the emerging notion that E2F4 is
themost versatile member of the E2F familywith divergent roles in various
tissues and cell types.Weprovide amechanistic basis for the apparent
phenomenological links in the two main tissues where ABCB10
function has been postulated: erythroid haematopoietic cells and
cardiomyocytes. Our findings will be important for the ongoing work
on elucidation of ABCB10 physiological role aswell as for understanding
some corollaries of E2F4 function and its disruption.