Abstract
Diarrhea is a common complication associated with allogeneic and autologous stem cell transplant patients. One potential
cause of viral diarrhea is rotavirus gastroenteritis. This study represents a single-center experience of using multiple
daily doses of enteral immunoglobulins in four pediatric hematopoietic stem cell transplant patients with confirmed
rotavirus infections. Four courses of enteral immunoglobulin administration were included for analysis. Clinical characteristics
recorded included duration of diarrhea symptoms, frequency of bowel movements, and consistency of stool.
Four single courses of enteral immunoglobulins in four patients were included for analysis. Patient age range was from
10 months to 14 years. Three out of four courses observed displayed an improvement in diarrhea frequency and/or stool
consistency. Median time from therapy initiation to symptom improvement was three days. At a median 22-month
follow-up, one patient was diagnosed with gastrointestinal graft-versus-host disease. The time to rotavirus symptom
resolution was decreased, compared to historical controls, and improvement in stool frequency and consistency was
observed in three of four courses. One case of gastrointestinal graft-versus-host disease was observed after nearly two
years of follow-up. Enteral administration of immunoglobulins may represent a valid clinical option for hematopoietic
stem cell transplant patients with rotavirus diarrhea.