Although a previous review has provided an excellent general overview of Bacopa’s reputed health benefits,to the authors’ knowledge, no study has systematically reviewed the cognitive-enhancing effects of Bacopa in humans. Furthermore, since the review by Russo and Borrelli, several key trials in the area have surfaced. Consequently, this review aimed to qualitatively examine the cognitive-enhancing effects of Bacopa in humans. A qualitative systematic review of relevant trials was performed to explore the longterm effects of Bacopa extracts on any validated cognitive outcome.