Most people associate the use of rabbits in laboratories with toxicity testing for cosmetic, personal, and household products. The best-known tests are the Draize eye and skin irritancy tests, which are extremely painful and cruel. While being experimented upon, rabbits are often locked into full-body restraints to prevent them from touching eye or skin sores. These tests are not very reliable, and increasing attention is being paid to the development of alternatives to replace the use of rabbits for these categories of toxicity testing.