To date, only a few papers have been reported on determination of carvedilol using spectrophotometry [42], chemiluminescence [43] and spectroflurimetry [44e47], in all of which carvedilol was determined only in pharmaceutical dosage forms and tablets.
In this study, a new approach was developed for the first time in which a poly acrylate-ethylene glycol (PA-EG) thin film was prepared
. Application of methyl methacrylate (MMA) as the monomer and ethyleneglycol dimethacrylate (EGDMA) as cross-linker donates more polar characteristic to the coating, hence the possibility to extract compounds with low Ko/w.
Effect of different contents of monomer and cross-linker on the mechanical property and solvent resistance of the prepared thin films were investigated.