Transgenic mice
Six- to 8-week-old triple transgenic (3xTg-AD) mice and age-matched
non-transgenic (NonTg) controls were used in all experiments. The derivation
and characterization of the 3xTg-AD (APPswe, TauP301L, and
PS1M146VKI) mice have been described previously (Oddo et al., 2003).
NonTg control mice were of the same background strain (129/C57BL/6)
as the 3xTg-AD mice.