All the animals were housed in appropriate cages at standard controlled laboratory condition (23°C, 12 h light/dark cycle). Water and food were easily available to all experimental animals during acclimatization period. Food was withdrawn from all animals 18 hrs before starting the experiment.The animals were randomly divided into five groups.This study was approved by the ethical committee of Department of Pharmacy, University of Malakand according to animals Bye-Laws 2008 (Scientific procedure
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