In this context, Madách and colleagues aimed to prospectively evaluate 207 Caucasian patients with pneumonia-induced severe sepsis for the effects of the 4G/5G and 4G/4G polymorphisms of the PAI-1 gene, in which the 4G allele results in greater transcription of the gene. The authors showed that carriers of the two poly-morphisms, compared with those of the 5G/5G poly-morphism, had higher disseminated intravascular coagu-lation scores and had a 2.74-fold higher risk of MODS
and a 2.57-fold higher risk of septic shock.