In all the vestipitant treatmentgroups, the reasons for treatment
failure were primarily due to the requirement for further
rescue medication (35%), rather than being due to emesis and
retching (9%). In contrast, the reasons for treatment failure in
the ondansetron arm were predominantly due to emesis and retching (37%) compared with the need for further rescue
medication (21%). Similar results were obtained when data
excluded six patients with major protocol deviations.