On-line coupling of high-performance liquid chromatography
and high-resolution capillary gas chromatography (LC-GC) provides numerous advantages for the analysis of complex mixtures,
as it combines the effectiveness of the sample preparation
achievable in the LC step with the high efficiency and sensitivity
of GC. This combination provides lower detection limits for
analytes than both techniques separately.
19,20
On-line combinations
of the sample preparation followed by chromatographic analysis