The resolution of high-resolution instruments can be changed by adjusting the width of the entrance and exit slits into the spectrometer. Typical HR-ICP-MS instruments have resolving powers up to 10,000 and are typically operated at preset resolution settings for low, medium or high-resolution to make their operation easier for the user. As we can see from Table 1, the use of HR-ICP-MS will solve many, but not all interference problems.